聚乙二醇维生素E琥珀酸酯在药剂学中的应用进展

郑楠楠,吴琳华,唐景玲*

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (16) : 1373-1376.

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PDF(632 KB)
中国药学杂志 ›› 2014, Vol. 49 ›› Issue (16) : 1373-1376. DOI: 10.11669/cpj.2014.16.001
综述

聚乙二醇维生素E琥珀酸酯在药剂学中的应用进展

  • 郑楠楠1,吴琳华2,唐景玲1*
作者信息 +

Advance in Application of D-α-Tocopherol Polyethyleneglycol Succinate in the Field of Pharmaceutics

  • ZHENG Nan-nan1, WU Ling-Hua2, TANG Jing-ling1*
Author information +
文章历史 +

摘要

目的 综述聚乙二醇维生素E琥珀酸酯(TPGS)作为药物载体的最新进展。方法 根据国内外公开发表的文献,对琥珀酸酯的理化性质、安全性及作为药物载体的应用加以分析和讨论。结果与结论 琥珀酸酯可以在药物传递系统中作为乳化剂、增溶剂、增塑剂、多药耐药逆转剂等,提高药物的治疗效果。其作为药物载体在药学领域中的应用前景广阔。

Abstract

OBJECTIVE To review the applications of D-α-tocopherol polyethylene glycol succinate (TPGS) as a drug carrier in pharmaceutical preparation. METHODS Based on the recently published papers, the research on the application of TPGS was classified and summarized. RESULTS AND CONCLUSION TPGS has been extensively applied as a pharmaceutical excipient, such as solubilizing agent, multidrug resistance reversing drug, emulsifier, plasticizer and vehicle for controlled drug delivery systems. As a safe and effective pharmaceutical excipient, TPGS has a very good prospect in the field of pharmaceutics.

关键词

聚乙二醇维生素E琥珀酸酯(TPGS) / 辅料 / 药物载体

Key words

D-α-tocopherol polyethyleneglycol succinate (TPGS) / excipient / drug carrier

引用本文

导出引用
郑楠楠,吴琳华,唐景玲*. 聚乙二醇维生素E琥珀酸酯在药剂学中的应用进展[J]. 中国药学杂志, 2014, 49(16): 1373-1376 https://doi.org/10.11669/cpj.2014.16.001
ZHENG Nan-nan, WU Ling-Hua, TANG Jing-ling*. Advance in Application of D-α-Tocopherol Polyethyleneglycol Succinate in the Field of Pharmaceutics[J]. Chinese Pharmaceutical Journal, 2014, 49(16): 1373-1376 https://doi.org/10.11669/cpj.2014.16.001
中图分类号: R944   

参考文献

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基金

国家自然科学基金资助项目(81302705)
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